Research

The focus of the Evergrande Center on chronic inflammation is prompted by the astounding rise in inflammatory diseases to epidemic levels in recent years. For example, Inflammatory Bowel Disease (IBD) rates have increased six-fold over the past three decades and the incidence of food allergies has doubled in the last fifteen years. To address this global public health crisis, the Evergrande Center brings together renowned experts with different areas of research expertise who will work together to systematically develop tools and technologies to better understand the pathways mediating chronic inflammation.  Together Evergrande scientists will leverage their knowledge and experience towards the goal of developing more effective treatments for those living with these challenging diseases. The Evergrande Center has identified 5 major research areas that will form the basis of the integrated approach towards a better understanding of how chronic inflammation drives tissue inflammation in different tissues.

Microbes and tumors are the smartest immunologists because they've stolen the tolerance-inducing or inhibitory pathways that are the most important, using them to evade immune eradication."

 

Arlene Sharpe, Co-Director

One of the morals of the story is, regulatory T cells can control critical, non-immune processes."

 

Diane Mathis, Core Faculty

Autoimmune Diseases

In autoimmune diseases such as Multiple Sclerosis, Type 1 Diabetes, and Rheumatoid Arthritis, self-reactive T and B cells escape regulatory checkpoints in lymphoid tissues where they develop and expand. 

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Cancer Immunotherapy

Center researchers are actively working on how to best target immune checkpoint receptors, a class of molecules whose function is to diminish inflammation, for the treatment of cancer. 

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Environmental Triggers

Multiple pollutants may be responsible for increased immune and inflammatory diseases in industrialized countries. Further research is required to identify and explore these triggers.

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Metabolic Diseases

The prevalence of obesity and diabetes is increasing world-wide, and although increasing energy consumption and reduced physical exercise play key roles, data suggest that chronic low-grade inflammation is the underlying cause.  

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Neurologic Diseases

We will investigate how interactions between the immune system and the nervous system can drive changes in neuronal activity, survival, and central nervous system health.  

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