The focus of the Evergrande Center on chronic inflammation is prompted by the astounding rise in inflammatory diseases to epidemic levels in recent years. For example, Inflammatory Bowel Disease (IBD) rates have increased six-fold over the past three decades and the incidence of food allergies has doubled in the last fifteen years. To address this global public health crisis, the Evergrande Center brings together renowned experts with different areas of research expertise who will work together to systematically develop tools and technologies to better understand the pathways mediating chronic inflammation. Together Evergrande scientists will leverage their knowledge and experience towards the goal of developing more effective treatments for those living with these challenging diseases. The Evergrande Center has identified 5 major research areas that will form the basis of the integrated approach towards a better understanding of how chronic inflammation drives tissue inflammation in different tissues.
“Microbes and tumors are the smartest immunologists because they've stolen the tolerance-inducing or inhibitory pathways that are the most important, using them to evade immune eradication."
Arlene Sharpe, Co-Director
“One of the morals of the story is, regulatory T cells can control critical, non-immune processes."
Diane Mathis, Core Faculty
The Evergrande Center’s Flagship project combines the expertise of the Evergrande Core Faculty together with that of prominent scientists and clinicians across the greater Harvard community in a multi-institutional effort to address a common goal: to make immunotherapy for colorectal cancer a reality.