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Welcome Martin Hemberg!

February 17, 2021
The Evergrande Center is thrilled to be expanding our core faculty with the addition of Dr. Martin Hemberg. His research focuses on quantitative models of gene expression enhancing the expertise of our Center. Dr. Hemberg's laboratory will be located at Brigham & Women's Hospital. Welcome, Martin!
Vijay Kuchroo wins William E. Paul Award for Excellence in Cytokine Research

Vijay Kuchroo wins William E. Paul Award for Excellence in Cytokine Research

December 23, 2020

Vijay Kuchroo, DVM, PhD, of the Department of Neurology, received the BioLegend William E. Paul Award from the International Cytokine and Interferon Society (ICIS) for advancing understanding of the cytokine interleukin17 (IL-17) in health and disease. This award recognizes leading biomedical scientists who have made substantial contributions to research on cytokines, small proteins instrumental in immune activity. 

Kuchroo shares the award with Sarah Gaffen, PhD, of the Pittsburg School of Medicine. The two researchers have conducted groundbreaking work characterizing...

Read more about Vijay Kuchroo wins William E. Paul Award for Excellence in Cytokine Research
Howard Weiner

Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells

December 1, 2020
Identifying signaling pathways contributing to resistance to anti-TNF therapy in rheumatoid arthritis is crucial for the development of new therapeutic strategies for refractory rheumatoid arthritis as described in a paper from the Weiner lab. Th17 cells, a subset of proinflammatory CD4+ T cells, are implicated in the pathogenesis of the disease. We analyzed the gene expression profiles of Th17-enriched CD4+ T cells in anti-TNF–treated patients with rheumatoid arthritis and found that the elevated expression levels of transcription factor USF2 in anti-TNF refractory... Read more about Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells
An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets

An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets

November 24, 2020
The Kuchroo lab has published new work in Cell Reports showing interleukin-27 (IL-27) is an immunoregulatory cytokine that suppresses inflammation through multiple mechanisms, including induction of IL-10, but the transcriptional network mediating its diverse functions remains unclear. Combining temporal RNA profiling with computational algorithms, we predict 79 transcription factors induced by IL-27 in T cells. We validate 11 known and... Read more about An IL-27-driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets
Howard Weiner

The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity

October 29, 2020
While the risk of developing multiple sclerosis (MS) is recognized to have both genetic and environmental components, little is known about these complex interactions. The microbiome has recently been recognized as an environmental factor that contributes to MS. In Montgomery et al. (1), the authors harnessed the natural genetic diversity between B6 mice, PWD/PhJ (PWD) wild-derived mice, and a panel of 27 B6.ChrPWD consomic mice to investigate gene plus microbiome interactions. They identified chromosomes that affected disease susceptibility and also... Read more about The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity
Ana C. Anderson

Endogenous glucocorticoid signaling regulates CD8+ T cell differentiation and development of dysfunction in the tumor microenvironment

September 15, 2020
Identifying signals in the tumor microenvironment (TME) that shape CD8+ T cell phenotype can inform novel therapeutic approaches for cancer. In a paper published in Immunity, the Anderson lab identified a gradient of increasing glucocorticoid receptor (GR) expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes (TILs). Conditional deletion of the GR in CD8+ TILs improved effector differentiation, reduced expression of the transcription factor TCF-1, and inhibited the dysfunctional phenotype, culminating in tumor growth... Read more about Endogenous glucocorticoid signaling regulates CD8+ T cell differentiation and development of dysfunction in the tumor microenvironment