The Evergrande Center is thrilled to be expanding our core faculty with the addition of Dr. Martin Hemberg. His research focuses on quantitative models of gene expression enhancing the expertise of our Center. Dr. Hemberg's laboratory will be located at Brigham & Women's Hospital. Welcome, Martin!
Vijay Kuchroo, DVM, PhD, of the Department of Neurology, received the BioLegend William E. Paul Award from the International Cytokine and Interferon Society (ICIS) for advancing understanding of the cytokine interleukin17 (IL-17) in health and disease. This award recognizes leading biomedical scientists who have made substantial contributions to research on cytokines, small proteins instrumental in immune activity.
Kuchroo shares the award with Sarah Gaffen, PhD, of the Pittsburg School of Medicine. The two researchers have conducted groundbreaking work characterizing...
Work by Arlene Sharpe and Marcia Haigis ellucidates the link between obesity and increased cancer risk. A new study in mice published in Cell, has implicaitons for cancer immunotherapy. Read more. Read more about Obesity and Cancer
Identifying signaling pathways contributing to resistance to anti-TNF therapy in rheumatoid arthritis is crucial for the development of new therapeutic strategies for refractory rheumatoid arthritis as described in a paper from the Weiner lab. Th17 cells, a subset of proinflammatory CD4+ T cells, are implicated in the pathogenesis of the disease. We analyzed the gene expression profiles of Th17-enriched CD4+ T cells in anti-TNF–treated patients with rheumatoid arthritis and found that the elevated expression levels of transcription factor USF2 in anti-TNF refractory... Read more about Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells
While the risk of developing multiple sclerosis (MS) is recognized to have both genetic and environmental components, little is known about these complex interactions. The microbiome has recently been recognized as an environmental factor that contributes to MS. In Montgomery et al. (1), the authors harnessed the natural genetic diversity between B6 mice, PWD/PhJ (PWD) wild-derived mice, and a panel of 27 B6.ChrPWD consomic mice to investigate gene plus microbiome interactions. They identified chromosomes that affected disease susceptibility and also... Read more about The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity