Autoimmune Diseases

In autoimmune diseases such as Multiple Sclerosis, Type 1 Diabetes, and Rheumatoid Arthritis, self-reactive T and B cells escape regulatory checkpoints in lymphoid tissues where they develop and expand.  This leads to the generation of antibodies and cytotoxic cells, which destroy brain, pancreatic, and joint tissues, respectively. The Center is focused on basic research work, identifying cells and molecules involved in chronic inflammation.